Conference Agenda

The meeting will begin on Monday, August 7th with registration from 14:00 to 17:00. The opening address will begin at 16:00, followed by a keynote address at 17:00 and a welcome mixer and dinner from 18:00 to 20:00. Conference events conclude on Thursday, August 10th with a closing dinner from 18:00 to 20:00. We recommend return travel on Friday, August 11th in order to fully experience the meeting. 

All events are scheduled within the Michigan League unless otherwise noted.

No registration fees are used to fund the alcohol served in conjunction with this conference.

 

Monday, August 7

14:00 - 16:45

Arrival and Registration – Michigan League Concourse (2nd Floor)

16:45  - 17:00

Opening and Welcome Address

Vincent B. Young, M.D., Ph.D., University of Michigan, United States

Michigan League Ballroom (2nd Floor)

17:00 – 18:00

Keynote LectureLinc Sonenshein, Ph.D., Tufts University, USA.  Co-regulation of sporulation and virulence in C. difficile

18:00 – 20:00

Welcome Mixer - Dinner

20:00 – 21:00

Late Registration – Michigan League Concourse (2nd Floor)

 

Tuesday, August 8

 

Session 1: Toxins I

Michigan League Ballroom

Chair: Dena Lyras, Monash University, Australia

07:00 – 08:00

Late Registration – Michigan League Concourse

08:00 – 08:45

State of the Art LectureBorden Lacy, Ph.D., Vanderbilt University, USA. Structure and Function of Clostridial Toxins

08:45 – 09:00

Abstract presentation: Archana Shrestha, Ph.D., University of Pittsburgh, USA. Bystander Host Cell Killing Effects of Clostridium perfringens Enterotoxin

09:00 – 09:30

Invited SpeakerMichel Popoff, D.V.M., Ph.D., Pasteur Institute, FRA. Novel insights in the molecular activity of Clostridial toxins

09:30 – 09:45

Abstract presentation: Heather Kroh, Ph.D., Vanderbilt University Medical Center, USA. A neutralizing antibody that blocks Clostridium difficile toxin TcdB enzyme delivery

09:45 – 10:00

Abstract presentation: Andreas Rummel, Ph.D., Medizinische Hochschule Hannover, Germany. Insights into the interaction of clostridial neurotoxin associated proteins

10:00 – 10:30

Coffee Break

 

Session 2: Microbiome / Anaerobic Microbial Ecology

Michigan League Ballroom

Chair: Casey Theriot, North Carolina State University College of Veterinary Medicine, United States

10:30 – 11:00

Invited SpeakerRobert Britton, Ph.D., Baylor College of Medicine, USA. Diet induced evolution of epidemic C. difficile

11:00 – 11:15

Abstract presentation: Melinda Engevik, Ph.D., Baylor College of Medicine, USA. Fusobacterium nucleatum promotes Clostridium difficile colonization in human intestinal mucus-based biofilms

11:15 – 11:30

Abstract presentation: Paul Carlson, Ph.D., Food and Drug Administration, USA. MAIT cells alter the murine microbiome reducing colonization resistance against Clostridium difficile 

11:30 – 12:00

Invited SpeakerGayatri Vedantam, Ph.D., University of Arizona, USA. Non-toxin Factors Impacting C. difficile Colonization and Virulence

12:00 – 12:15

Abstract presentation: Neil Surana, M.D., Ph.D., Boston Children's Hospital, USA. A disease-protective human commensal discovered using microbial pedigree analysis

12:15 – 12:30

Abstract presentation: Jae Hyun Shin, M.D., University of Virginia, USA. Innate immune response and outcome of Clostridium difficile infection are dependent on fecal bacterial composition in the aged host

12:30 – 14:00

Lunch: Synthetic Biologics Lunch Symposium

 

Session 3: Toxins II

Michigan League Ballroom

Chair: Jimmy Ballard, University of Oklahoma-HSC, United States

14:00 – 14:30

Invited SpeakerBruno Dupuy, Ph.D., Pasteur Institute, FRA. Cwp19-dependent toxin release in Clostridium difficile

14:30 – 14:45

Abstract presentation: Miia Lindström, D.V.M., Ph.D., University of Helsinki, Finland. First glance into single-cell-level neurotoxin expression in Clostridium botulinum cultures

14:45 – 15:00

Abstract presentation: Rita Tamayo, Ph.D., University of North Carolina at Chapel Hill, USA. The DNA recombinase RecV mediates phase variation of Clostridium difficile flagellum and toxin production

15:00 – 15:30

Invited SpeakerMin Dong, Ph.D., Harvard Medical School, USA. Genome-wide CRISPR screens reveal receptors for C. difficile toxin B

Sponsored by Toxins open access journal

15:30 – 15:45

Abstract presentation: Stephen Melville, Ph.D., Virginia Polytechnic Institute and State University, USA. A Type II-like secretion system in Clostridium perfringens?

15:45 – 16:00

Abstract presentation: Shengjie Guo, Peking University, China. Identification of Alternative Receptors for Clostridium difficile Toxin B Through High-Throughput CRISPR Screen

16:00 – 16:45

Flash Talk Session #1

·       Alyse Frisbee

·       Ana Paiva

·       Christopher Lopez

·       Emily Wolfrum

·       Heather Danhof

·       Himani Kaushik

·       Hua Yu

·       Jackie Cheung

·      Jingze Liu

·      John C. Freedman

·      Kathleen McAllister


16:45 – 18:00

Poster Session I

Michigan League Hussey & Vandenberg Rooms

18:30

Dinner

Michigan Union – Rogel Ballroom

 

Wednesday, August 9

 

Session 4: One Health: Pathogenesis & Microbial Ecology

Michigan League Ballroom

Chair: Francisco Uzal, University of California-Davis, United States

07:00 – 08:00

Late Registration – Michigan League Concourse

08:00 – 08:45

State of the Art LectureWilliam Petri, M.D., Ph.D., University of Virginia School of Medicine, USA. Harnessing innate immunity to prevent and treat C. difficile

08:45 – 09:00

Abstract presentation: Michael Abt, Ph.D., Memorial Sloane Kettering Cancer Center, USA. Host immune response supports fecal microbiota transplant-mediated clearance of Clostridium difficile infection

09:00 – 09:30

Invited SpeakerRobert Moore, Ph.D., Royal Melbourne Institute of Technology University, Australia. Title: Toxins in veterinary Clostridial infections

09:30 – 10:00

Invited SpeakerKlaus Aktories, M.D., Ph.D., University of Freiburg, Germany. Toxins in human Clostridial infections

 10:00 – 10:15

 Abstract presentation: Danielle D'Souza, Monash University, Australia. Identification of a novel clostridial myonecrosis virulence factor, CnaE

10:15 – 10:30

Coffee Break

 

Session 5: One Health: Microbial Ecology

Michigan League Ballroom

Chair: Vincent Young, University of Michigan, United States

10:30 – 11:00

Invited SpeakerCasey Theriot, Ph.D., North Carolina State University College of Veterinary Medicine, USA, Targeted bacterial restoration of colonization resistance against C. difficile in the gastrointestinal tract

11:00 – 11:15

Abstract presentation: Daniel Paredes-Sabja, Ph.D., Andrés Bello National University, Chile. Clostridium difficile spore-host interactions: Revealing the mechanism of persistence of Clostridium difficile spores in the intestinal epithelium and its role in recurrent disease

11:15 – 11:30

Abstract presentation: Anna Seekatz, Ph.D., University of Michigan, USA. Individualized Recovery of the Microbiota and Microbial Metabolites Over Time Following Fecal Microbiota Transplantation in Patients with recurrent Clostridium difficile Infection

11:30 – 12:00

Invited SpeakerFilip van Immerseel, Ph.D., Ghent University, Belgium. Development of prophylactic solutions for avian necrotic enteritis based on microbial ecological knowledge

12:00 – 12:30

Invited Speaker: J. Scott WeeseD.V.M., D.V.Sc., Dip.A.C.V.I.M., University of Guelph, Canada. C. difficile in humans and animals

12:30 – 13:30

Lunch

 

Session 6: One Health: Epi / Treatment

Michigan League Ballroom

Chair: David Aronoff, Vanderbilt University, United States

13:30 – 14:00

Invited SpeakerFrancisco UzalD.V.M., Ph.D., D.A.C.V.P., University of California-Davis, USA. Comparative pathogenesis of Clostridial infections in humans and animals

14:00 – 14:15

Abstract presentation: Shifeng Wang, Ph.D., University of Florida, USA. Triple-sugar regulated Salmonella Vaccines protect against Clostridium perfringens-induced necrotic enteritis in broiler chickens

14:15 – 14:30

Abstract presentation: Roman Melnyk, Ph.D., University of Toronto, CA.      A Host-Targeted Antivirulence Molecule Prevents C. difficile Disease Pathogenesis in Mice

14:30 – 15:00

Invited Speaker: : Vivian Loo, M.D., M.Sc., McGill University, Canada. Update on Epidemiology and Management of human Clostridium difficile infections

15:00 – 15:30

Invited Speaker: Thomas Riley, Ph.D., University of Western Australia, Australia. One Health: Lessons from Australia

15:30 – 15:45

Special talk/discussion session: Julian Rood, Monash University, Australia

Expansion of the C. perfringens toxinotyping scheme

15:45

Networking activities - Participants make their own dining plans

 

Thursday, August 10

 

Session 7: Spore dynamics

Michigan League Ballroom

Chair: Aimee Shen, Tufts University, United States

08:00 – 08:15

Abstract presentation: Travis Kochan, University of Michigan, USA. Intestinal Calcium Coordinates with Bile Salts to Facilitate Germination of Clostridium difficile Spores

08:15 – 08:30

Abstract presentation: Mayo Yasugi, Ph.D., Osaka Prefecture University, Japan. Deoxycholate induced sporulation by facilitating Spo0A phosphorylation in Clostridium perfringens

08:30 – 08:45

Abstract presentation: Megan Touchette, Ph.D., Tufts University School of Medicine, USA. SpoIVA-SipL complex is essential for functional spore formation in Clostridium difficile

08:45 – 09:15

Invited SpeakerJoseph Sorg, Ph.D., Texas A&M University, USA. Conservation of a novel spore germination pathway outside of Clostridioides difficile

09:15 – 09:30

Abstract presentation: Adrianne Edwards, Ph.D., Emory University, USA. Regulation of Toxin Production and Sporulation in Clostridium difficile by the Multifunctional Protein, RstA

09:30 – 09:45

Abstract presentation: John Ribis, Tufts University, USA. The role of conserved peptidoglycan hydrolases during Clostridium difficile spore formation

09:45 – 10:15

Coffee Break

 

Session 8: Clostridial Pathogenesis: Basic Mechanisms

Michigan League Ballroom

Chair: Gayatri Vedantam, University of Arizona, United States

10:15 – 10:45

Shimizu LectureDena Lyras, Ph.D., Monash University, Australia. The regulation of toxin production in pathogenic clostridia

10:45 – 11:00

Abstract presentation: Nicolas Kint, Institut Pasteur, France. The alternative sigma factor SigB plays a crucial role in adaptive strategies of Clostridium difficile during gut infection

11:00 – 11:15

Abstract presentation: Tavan Janvislisci, Ph.D., Mahidol University, Thailand. An ABC transporter potentially mediates multidrug efflux in Clostridium difficile

11:15 – 11:45

Invited SpeakerJihong Li, Ph.D., University of Pittsburgh, School of Medicine, USA. Potential contributions of NanI sialidase to Clostridium perfringens enteric pathogenesis

11:45 – 12:00

Abstract presentation: Daphne Groothius, University of Nottingham, UK. CRISPR/Cas9 Genome Editing in Pathogenic Clostridia

12:00 – 12:15

Abstract presentation: Heloise Coullon, University of Paris-Sud, France. PgdA is the major peptidoglycan N-deacetylase of Clostridium difficile

12:15 – 12:45

Invited SpeakerJulian Rood, Ph.D., Monash University, Australia. Clostridium perfringens-mediated mynecrosis: It is not all about toxins

12:45 – 14:00

Lunch

 

Session 9: Clostridial Pathogenesis: Genomics, Regulation, Epidemiology, Therapy

Michigan League Ballroom

Chair: Borden Lacy, Vanderbilt University, United States

14:00 – 14:30

Invited SpeakerRobert Fagan, Ph.D., University of Sheffield, UK.  Cracking a difficult crystal shell

14:30 – 14:45

Abstract presentation: Shonna McBride, Ph.D., Emory University School of Medicine, USA. Discovery of an LL-37 response mechanism in Clostridium difficile

14:45 – 15:00

Abstract presentation: Larry Kociolek, M.D., MSCI, Northwestern University Feinberg School of Medicine, USA. Evolution and Transmission of a Multidrug-Resistant DH/NAP11/106 Clostridium difficile Clone in a Pediatric Hospital

15:00 – 15:15

Abstract presentation: Mahmoud Saleh, University of Virginia, USA. CD4+ T Cells Play a Pathogenic Role during Clostridium difficile Infection in Hosts with a History of Colitis

15:15 – 15:30

Abstract presentation: David Aronoff, M.D., FIDSA, Vanderbilt University, USA. Indomethacin Increases the Severity of Clostridium difficile in the Mouse and Alters the Immune Phenotype

15:30 – 16:00

Invited SpeakerNeil Fairweather, Ph.D., Imperial College London, UK. The C. difficile cell wall - latest developments and a career retrospective

16:00 – 16:45

Flash Oral Poster Session #2

·       Melanie Hutton

·      Milena Awad   

·       Raquel Rodrigues

·       Reece Knippel

·       Ritu Shrestha

·       Sarah Miller

·       Stacey Hong

·       Stephanie Spohn

·       Susanne Sievers

·       Tom Bailey

·       Zhong Peng

16:45 – 18:00

Poster Session II

Michigan League Hussey & Vandenberg Rooms

18:30

Closing Summary, Conference Dinner, Student/Trainee Awards

University of Michigan Museum of Art (UMMA)

 

Friday, August 11 - Departure